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KMID : 0939920020340020117
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대한암학회지
2002 Volume.34 No. 2 p.117 ~ p.121
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Immunohistochemical Study of β-catenin Expression between Hepatocellular Carcinoma and Cholangiocarcinoma
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Ki Jung Yun/Ki Jung Yun
Weon Cheol Han/Suck Chei Choi*/Tae Hyeon Kim*
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Abstract
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Purpose: beta-catenin is an intracellular protein that is an integral component of the cadherin-mediated cell-cell interaction and a downstream transcriptional activator in the wnt signal transduction pathway. Inappropriate activation of beta-catenin has recently been implicated in the development of hepatocellular carcinoma and cholangiocarcinoma. Nuclear beta-catenin expression is strongly associated with gene mutation. This study was designed to evaluate the pattern of beta-catenin expression between hepatocellular carcinoma and cholangiocarcinoma.
Materials and methods: Immunohistochemical expression of beta-catenin was studied in 7 normal livers, 33 hepatocellular carcinomas and 20 cholangiocarcinomas, that were formalin fixed and paraffin embedded.
Results: beta-catenin was expressed mainly in the cytoplasmic membrane of the normal hepatocytes and bile ducts. Nuclear expressions, not noted in the normal liver, were noted in 30% of the hepatocellular carcinomas and 10% of the cholangiocarcinomas. And, nuclear expression was more common in the high grade (50%) hepatocellular carcinomas than the low grade (18%) hepatocellular carcinomas (p<=0.05).
Conclusion: The above results indicate that nuclear expression of beta-catenin is observed in the carcinoma but not the normal liver, and is associated with high grade liver carcinoma.
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KEYWORD
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Hepatocellular carcinoma, Cholangiocarcinoma, β-catenin,
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